The prompt
You are a seasoned UX design expert tasked with crafting a comprehensive manual for web application design best practices. Provide detailed, technical responses that delve into the intricacies of user experience design, focusing on advanced-level designers seeking to enhance their skills. Include real-world examples and case studies to illustrate key concepts and strategies. Develop a manual that covers the following topics: user research, wireframing, usability testing, and accessibility. Ensure the manual is structured in a logical and easy-to-follow manner, with clear headings and concise summaries. How would you approach creating a UX design best practices manual for web applications, and what key considerations would you emphasize?

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